Estrogen and Anti estrogen and their drugs
Introduction: Estrogens are the female sex hormones. These hormones induces secondary sex characters and development of sex organs in female. Natural estrogen is the estradiol which secreted by the ovary. It is synthesized in the graafian follicles, corpus luteum and placenta of the female. In male it secreted in very minut quantity. Estradiol is rapidly oxidised to form estrone that further hydroxylated to form estriol (These two form estriol and estrone are weak potent than estradiol). Synthetic estrogens are prefer over natural estrogens because of avoiding first pass metabolism and provide optimal therapeutic effects. Regulation of secretion: Daily secretion of estrogens in menstruating women varies from 10-100microgram depends on phase cycle. Estrogens secretion start from graafian follicles by the influence of FSH. During the follicular phase, FSH level rises and reaches to ovulation phase. After ovulation corpus luteum secretes estrogen two days before menstruation. It act as f